Dror Zerem, FIZE Medical - Advanced iOU Monitoring Devices | LSI USA '24

Dror Zerem  0:04  
Hi everyone, my name is Dror Zerem and I'm the CEO of FIZE Medical. Our mission is to prevent acute kidney injury through accurate real time. During output monitoring and predictive AI analytics, our leadership team at Pfizer is comprised of a successful professionals with vast experience in medical device field. All the way to exit and our team is currently consists of 37 individuals with deep knowledge in the medical device field r&d, production, sales, marketing and regulatory. Were also guided by a growing body of renowned key opinion leaders in the field of Urology in a critical care. So what is exactly acute kidney injury? And why is it such a big problem? acute kidney injury is a sudden episode of kidney failure or kidney damage that happens within a few hours or a few days, which causes a buildup of waste products in your blood and makes it hard for your kidneys to keep the right right balance of fluid in your body. acute kidney injury can also affect the heart and other organs, the brain, the lungs, over 15% of admitted patients, of ICU patients. So up to 75% of Pediatrics ICU patients, and about 15% of all admitted patients develop acute kidney injury. It's a major issue. And its mortality is about 20% 20% mortality rate with these patients is so important that lately only few weeks ago, is the CMS as mandate Aki as a key reportable measure under its electronic quality measure program. It says it's well known that urine output is one of the two key markers of acute kidney injury. And in fact, it is used staging Aki, the faster we recognize there is a chance for acute kidney injury, the faster we can take care of these patients. So we have been monitoring you in output for decades. The same thing about six years. It's it's a it's typically a labor intensive manual process that is full of inaccuracies. You can see how it's done today in most hospitals, manual measurement, a lot of errors, delayed measurement, a missing measurements. It's really not a wonder a of a given how busy ICU nurses are. Okay, so it's really not very effective. And I talked about the results before about about 20% mortality rate and 50% of patients with Aki, one, the result it's a result of a been unable to really measure it in in real time. Okay, so it seems like a no brainer. I'm a physicist and the first time I heard about this order about this problem, I thought, what's what's so tough to measure you and output we measure in our houses, the water that comes in and we pay for that. So measuring you in output is almost the same. But it's not for almost 30 years. A lot of companies have tried just about every method to a you can think of to measure a un out output automatically. Some of the most notable are shown here including weighing the UN which is not accurate and requires a level floor, floor standing system ultrasonic sensor which have low resolution and also need to be flat and stable in thermal sensor which are also inaccurate, especially at low flows, which is where exactly is a problem. Our breakthrough in Phase Five is figuring out a way to sense each drop as it enters the blood coming from the kidneys enters the bladder, we measure every drops that comes there We don't measure it outside, when it goes outside, we measure it when it's entering the bladder. This gives us gives our monitor unparalleled accuracy with microliter resolution. It's even accurate for pediatrics and neonates, which consists of about 20% of the market. Because our monitor measures every drop in real time, we can provide early alerts to help reduce API and better react to interventions by the doctors. Sometimes you when you give fluids, we want to see the reaction takes 15 to 30 minutes, we can see the reaction to three, four minutes, sometimes even earlier. It's it's very important. In because we use a pump device, can you mount anywhere in any position on the bed or near the bed, and even works in transport, which is a very big usability problem with other devices. Our patented systems make us a clear leader in the space in the two most important metrics accuracy and usability. Any system that is hard for the nurses to use or interferes with the flow in the ICU simply will not be adapted. That's such a basic thing. Accuracy sometimes is even less important than usability, especially in the ICU and oppression rule sets. We know that we have hit the mark because in every hospital that we have installed the cable system, we get extremely positive feedback from the nursing stuff. Okay, even though we just launched the the key wall late last year, we are we already have a lot of traction. And we have signed contracts with the largest GPIOs here in the US present in Premiere that represent about 5000 hospitals 65% of hospitals in the US, we have our first commercial customer in the US and Israel and we're in pilots are entering pilots with a another 11 premier hospitals. Pfizer was also awarded a sole source contract with the largest health insurance provider in Israel. I know it's not the US but in our territory is the largest one, it's a good sign. We're also in finance negotiation with a leader in the kidney space for distribution in the Japanese market. We're in the process of turning Queijo besides doing the urine output, we are in process of making it a complete platform for urine analysis in AI driven Analytics, which we believe will be able to anticipate development of Aki or shock much earlier much earlier than today. I mean hours and sometimes even days, leading to shorter ICU stays and lower costs for healthcare providers. To support our sales, growth in the US in other markets and to accelerate development of our AI analytics, we are currently raising ces a for round of $15 million. To date, we have raised almost $50 million anchored by our lead investor Rafa capital from Florida and we have commitments for $8 million of this round. And we hope to be able to circle the rest in the next few months. We would welcome meeting with investors one on one behavior in the next two days. we're interesting in join us in reducing the tremendous burden of Aki for the betterment of patients care providers in the entire health health system. Thank you