Vikash Goel Presents Centerline Biomedical at LSI USA ‘23

Transcription

Vikash Goel  0:05  

Thanks. Glad to be here at at LSI again, a great community. So I'm Vikash Goel, you're the CTO and Founder of Centerline, you may be able to guess by the sunglasses, I'm also an optimist. I do hope the weather it'll improve, but also, you know, I really value having the right equipment to see. And so that's what we're going to talk about here. So let's just imagine here, right, that we're not in this room that we're actually out swimming. Maybe we're diving for oysters. Something's wrong, right? Where the hell are the oysters? Oh, we forgot our goggles. Great. So if you have the right equipment to see, it's a completely different experience. So let's look at another example of that this woman here. This is Dorothy love it. She in the late 1800s. And the early 1900s, was considered the fastest woman on earth. She held a water speed record, the women's land speed record. She was also though an author and an innovator. This book that she published in 1906 recommended something that the time was novel. It was a book about how to drive and I think it was targeted specifically at women, but in general, it was, um, she recommended, maybe you put a mirror somewhere there so you can see what's happening behind you. Maybe that'll help when you're driving. Well, a little bit later, in 1911 Ray Haroon took her idea to heart. He was racing in the Indianpolis 500. For the first time, that was the first Indy 500. And he mounted a mirror to his car. Oh, that's interesting. All the judges, they were here. They didn't know what to do with this. Some of them thought he was cheating. There was a lot of brouhaha. Well, they did eventually let him race and he took first place. So this is why it's so important to have the right stuff to see. And we wouldn't think of getting in a car that didn't have mirrors today. Right? Not one, but three, right? That's what we expect to see. Also, we have those backup cameras, those are required by law in the US now. But that feeling of trying to drive without mirrors or swim without goggles, actually happens 4 million times a year in the medical context. And I'm talking about X ray fluoroscopy. I think a lot of you are familiar with this image guidance technology. It's how we do these minimally invasive surgeries, vascular, cardiovascular, orthopedic, you know, many, many different types. What we're seeing here is a fluoro guided procedure being done at Cleveland Clinic actually to, to put a stent in a patient's aorta, those yellow yellow markers, those show where these arteries that you actually can't see are. So what we're talking about is repeated use of X-rays. This is like 20 X-Rays a second, lots of radiation, you can't actually see what you're doing. You see might see over on the left side of the screen there, there's a catheter, you can kind of make up the shadow of that this doctor is trying to use a wire and a catheter to get access to the artery going off to the right kidney, which is on the left side of the screen. I've sped this video up. So I don't bore everyone to tears, but I might just skip through it anyway, I think you can understand there's a lot of trial and error involved here. And this is an expensive place to do it. This room costs like $200 a minute to run. This is a doctor at Cleveland Clinic doing the same thing on a different patient with our technology, the magic tools to see. So you can immediately appreciate you can see the arteries in 3d, we can change the angles, however you want. That bright blue catheter, that green line is predicting where the wire is going to go. Now don't blink, he's going to pull the wire back and then shoot right into the artery on the first try. And then here we go. First try. So this is what centerline is founded on this is the idea that we want to improve the quality of image guidance, allow these procedures to be done better, faster, more accurately, and more safely get rid of this heavy dependence on fluoroscopic radiation, this ionizing radiation that we now know, is an occupational hazard to these physicians. So this is what centerlines a you know, at a glance, we found it in 2015 spun out from Cleveland Clinic. I was a researcher at Cleveland clinic's Heart and Vascular Institute and learner Research Institute. We develop this under the guidance of a world class endovascular surgeon where I Greenberg, Unfortunately, he passed away far too early. He was a he was 49 years old. But it was cancer. And you know, there may well have been a connection to these X rays. So that's a lot of where our passion and our motivation comes from. So our product and I'll tell you more about what it looks like. It's electromagnetic navigation, low level fields, not ionizing radiation. We got our FDA clearance and entered the market, just kind of at the start of the pandemic. So that's been fun. But we are in in our commercial launch. We're doing a controlled launch working with those centers event excellence that you'd expect, have a nice, strong moat, protecting us. So the closer 40 patents, and that's domestic and outside us. I'll tell you a little bit about our teams. And we've also gotten a lot of support not just from investors, but also from the government. And we've got a partnership working with the Air Force gotten for grants from the National Heartland Blood Institute. And last year, we did close on $33 million of funding. So what does the product itself look like? Well, it's kind of a razor and blade model. On the left of the screen, you see our system, it's this platform supporting all of these types of navigation. So kind of computer on wheels, there is an electromagnetic tracking system, it pops onto the table takes less than a minute to get it deployed in in any room that you would use it in. And then we have our consumable devices, wires and catheters, or registration pad, these things have sensors that we can localize in that field, and provide that guidance that you saw earlier, and that you see on the right of the screen here. So I hope it's kind of becoming clear what our value prop is here, where we're trying to improve efficiency, trying to improve radiation safety. I kind of glossed over this earlier. But there is this contrast dye that's used in these procedures, but you want to limit it, because it's toxic to the kidneys, there also has been a global supply shortage of it. So you know, we're trying to improve those things and ultimately improve the access to care by making procedures more accessible. And this stance have benefits for Well, essentially, everyone involved all the stakeholders in the health care system. We've been working, like I said, with, with really early adopter institutions to get get a lot of traction, get our product out there. We also have research partnerships with Cleveland Clinic and University of North Carolina. I can also speak a little bit about where we're going with this technology. We've got our clearance right now in the descending aorta, biggest artery in the body. This is where we have a lot of cases that are really long, really high radiation doses, where ultimately, ultimately the costs can exceed the reimbursement. But you've got an active development programs extending that indication to other parts of the body. One of the most interesting is structural heart, we've done a series of animal studies where we've actually been able to do some spectacular navigation through the structures of the heart in a way that's really, really challenging right now, when you mix, you know, Echo Cardiography with with X rays, and you know, you still can't really make out what's going on. But ultimately we see capabilities, we see applications essentially everywhere in the body, not just cardiovascular. If you're worried about our leadership, we've got myself subject matter expert, I've actually developed three navigation technologies for vascular interventions. Our CEO Gulam Khan, he's spent 20 years in med tech actually he has a great track record of he used to be CEO of us endoscopy, grew them by 600% exited them to Steris are head of operations Sonya Schneider. She's literally launched 40 medical devices in her career expert in Lean and, you know, the ISO standards and everything. Our CFO and President Frank Fedora wits has a lot of experience and leadership with small and medium med tech companies. Just a few words about our advisors to and if you work in the vascular space or the cardiac space, you may recognize some of these faces and names. We've been really fortunate to get a lot of support from the experts out in the field that really see the need for our technology. So that's uh, that center line in a nutshell. I'm really happy to be able to present this like this and look forward to connecting and partnering throughout LSI thanks a lot.